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Ibuprofen is a drug used to manage mild pain, fever, and inflammation. It is a chiral drug, and only the S enantiomer, whose specific rotation is 125.0°, is effective. The R enantiomer exhibits no biological activity. If a particular process is capable of producing ibuprofen in 84% enantiomeric excess of the S enantiomer, then what is the specific rotation of that mixture? What is the percentage S enantiomer in that mixture?

Answer :

SebasAime

Answer:

Specific Rotation = 105º

S% in mixture = 92%

Explanation:

Specific rotation in organic compounds varies linearly, then the enantiomeric excess can be express as:

[tex]e.e. = \frac{\alpha }{\alpha pure}[/tex]

Where alpha is the specific rotation of the mixture and alpha pure is the specific rotation of the excess enantiomer.

Then, knowing that the S enantiomer is in excess you can calculate the specific rotation of that mixture:

[tex]84=\frac{\alpha }{125.0}*100[/tex]

[tex]\alpha =105 Degrees[/tex]

For calculating the percentage of S you should remember that the enantiometric excess is the percentage of excess of a certain enantiomer, for example in this case:

[tex]84 = S-R[/tex]

Since S is in Excess

Also, it is true:

[tex]100=S+R[/tex]

Then you can solve the system of linear equations, finding:

[tex]8=R\\92=S[/tex]

Hope it helps!

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