The value of Δ????°′ΔG°′ for the conversion of glucose-6-phosphate to fructose-6-phosphate (F6P) is +1.67 kJ/mol+1.67 kJ/mol . If the concentration of glucose-6-phosphate at equilibrium is 1.85 mM1.85 mM , what is the concentration of fructose-6-phosphate? Assume a temperature of 25.0°C25.0°C .

Answer :

Answer : The concentration of fructose-6-phosphate is 0.275 mM

Explanation :

First we have to calculate the value of equilibrium constant.

The relation between the equilibrium constant and standard Gibbs free energy is:

[tex]\Delta G^o=-RT\times \ln k[/tex]

where,

[tex]\Delta G^o[/tex] = standard Gibbs free energy  = +1.67 kJ/mol = +1670 J/mol

R = gas constant  = 8.314 J/K.mol

T = temperature  = [tex]25.0^oC=273+25.0=298K[/tex]

K = equilibrium constant = ?

Now put all the given values in the above formula, we get:

[tex]+1670J/mol=-(8.314J/K.mol)\times (298K)\times \ln k[/tex]

[tex]k=0.509[/tex]

Now we have to calculate the concentration of fructose-6-phosphate.

The expression of equilibrium constant is:

[tex]K=\frac{[\text{fructose-6-phosphate}]}{[\text{glucose-6-phosphate}]}[/tex]

[tex]0.509=\frac{[\text{fructose-6-phosphate}]}{1.85mM}[/tex]

[tex]\text{fructose-6-phosphate}=0.275mM[/tex]

Therefore, the concentration of fructose-6-phosphate is 0.275 mM

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