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How would signaling be affected if a mutation caused a g protein to replace gdp with gtp on its own without needing to be activated by the g protein-coupled receptor?

Answer :

luisvaschetto

Answer:

This mutation will produce a conformational change capable of maintaining the receptor continuously in its activated mode

Explanation:

G proteins are inactive when guanosine diphosphate (GDP) is bound, while they are active when guanosine triphosphate (GTP) is bound

annyksl

In this case, the G protein would be activated and behave as a signaling protein, even if the presence of a ligand is not possible.

We can arrive at this answer because:

  • Changing GDP to GTP would cause a mutation, which would change the conformation of the protein.
  • However, this change would allow the activation of the protein, without the need for a ligand.
  • This is because the protein receptor is activated in the presence of GTP but is inactivated in the presence of GDP.

With that, we can affirm that the signaling would be permanently activated, without the presence of a ligand.

More information:

https://brainly.com/question/13129?referrer=searchResults

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