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Hey can someone please help with this ap bio question.
Read each question carefully. Write your response in the space provided for each part of each question. Answers must be written out in paragraph form. Outlines, bulleted lists, or diagrams alone are not acceptable and will not be scored.


The human kidney filters the blood to retain useful substances and remove waste products and excess water as urine. SLC3A1 and SLC7A9 are two different genes that each encode one part of a transporter protein complex typically found in the plasma membrane of human kidney cells. This transporter complex moves certain amino acids across the plasma membrane of the cells. Mutations in both the SLC3A1 and SLC7A9 genes are associated with increased levels of the polar amino acid cysteine in the urine, a condition called cystinuria. A researcher identified seven individuals with a family history of cystinuria. The researcher measured the concentration of cysteine in the urine of the seven individuals and sequenced their SLC3A1 and SLC7A9 genes to determine whether they carry functional (+) or mutant (−) alleles of genes. The results are shown in Table 1.

TABLE 1. CHARACTERISTICS OF SEVEN INDIVIDUALS WHO CARRY AT LEAST ONE MUTANT ALLELE
+ indicates the presence of a functional allele and − indicates the presence of a mutant allele.
Individual Concentration of Cysteine in Urine Relative to Normal Values
SLC3A1 Alleles SLC7A9 Alleles
1 32.2 −/− +/−
2 29.8 +/− −/−
3 11.0 −/− +/+
4 8.8 +/+ −/−
5 7.7 −/− +/+
6 2.3 +/+ +/−
7 0.5 +/− +/+
(a) Identify the individual who most likely exhibits symptoms of cystinuria.
(b) Describe the relationship between the total number of mutant alleles in an individual and the concentration of cysteine in the urine.
(c) Evaluate the hypothesis that mutations in SLC7A9 have a greater effect on the transport of cysteine across the plasma membrane of kidney cells than do mutations in SLC3A1.
(d) Explain how the data support the claim that cysteine is a large polar molecule.

Answer :

Answer:

a) Individual 1

b) Overall, the higher the number of mutant alleles, the greater is the concentration of cysteine in urine relative to normal values.

c) The hypothesis may be correct. If number of mutant allele in SLC7A9 is higher than number of mutant allele in SLC3A1, then concentration of cysteine  in urine is lower. This means that transportation of cysteine is affected by a greater extent if mutant allele in present in SLC7A9 genetic sequence

d) concentration of cysteine is affected by mutant allele which is a complex protien. If complex protien is low cysteine is not transported back and its concentration in urine is higher

Explanation:

a) Can be inferred easily from table. Higher the mutant allel that is negative, higher is the concentration of cysteine. Hence greater the chances of cystinuria.

b) As explained in part a

c) Observe the pattern on concentration of cycteine and number of - allele. If cysteine is not transported back then its concentration in urine will be higher.

d) The complex protien helps in transportatino of cysteine by binding to it. In the absence of the ocmplex protien, cysteine tends to behave like polar molecule and stay in water that is in excess in urine.

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