Answer :
The correct option among the following was DNA Methylation.
define DNA Methylation ?
A biological process called DNA methylation involves the addition of methyl groups to the DNA molecule. Without altering the sequence, methylation can modify the activity of a DNA region. DNA methylation often suppresses gene transcription when it occurs at a gene promoter. DNA methylation plays an important role in a variety of critical processes in mammals, including ageing, cancer, X-chromosome inactivation, genomic imprinting, and transposable element suppression.
Adenine and cytosine are the two nucleobases on which natural, enzymatic DNA methylation occurs as of 2016. N6-methyladenine[1], 5-methylcytosine[2], and N4-methylcytosine are the modified bases. [3]
The DNA nucleotide cytosine is methylated to create 5-methylcytosine at position 5 on the pyrimidine ring. This is the same place that separates thymine from the homologous RNA base uracil, which has no methyl group. 5-Methylcytosine undergoes spontaneous deamination and is changed into thymine. A T:G mismatch emerges from this. If A is substituted for G, the original C:G pair becomes a T:A pair, thus altering a base and producing a mutation. Repair mechanisms then fix it back to the original C:G pair.
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