Answer :
Humans who have Shh mutations or its aberrant expression have holoprosencephaly with severe symptoms such abnormal limb, face, and nervous system growth.
With an incidence of 1 in 250 embryos and 16,000 live births, holoprosencephaly (HPE) is a frequent brain development condition. A common midfacial cleft, such as a cleft lip or palate, is present in people with HPE because the cerebral hemisphere is not developed. Patients also have aberrant brain and facial development. Cyclopsis is a rare symptom of severe HPE cases (single eye). In addition to Shh mutations, downstream genes are also linked to this syndrome
learn more about holoprosencephaly here
https://brainly.com/question/17206288
#SPJ4