Answer :

That you are so upset/sad you basically go crazy

ANSWER:

The phrase "maddened by despair" refers to the state of being frustrated due to depression.

EXPLANATION:

Usage of the phrase maddened by despair in a sentence refers to the insane or frustrating behavior that a person makes when he is been subjected to grief and depression because of an incident.

Example:

Maddened by despair, the author wrote a novel that exhibited the pain and loneliness he underwent after the death of his daughter "the moment when I was aware of the sudden demise of my daughter, I would no longer wish to survive in this world". Here it expresses the grief of the author due to his daughter’s death.

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